2. Signaling Pathways
  3. GPCR/G Protein
  4. Adenosine Receptor

Adenosine Receptor

P1 receptor

Adenosine Receptor

Related Products

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Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor Isoform Specific Products:

Adenosine Receptor Isoform Comparison
Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-12365R
    Namodenoson (Standard)
    		Agonist
    Namodenoson (Standard) is the analytical standard of Namodenoson. This product is intended for research and analytical applications. Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (Ki=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.
    Namodenoson (Standard)
  • HY-155467
    MRS7935
    		Modulator
    MRS7935 (compound 15) is an A1AR positive allosteric modulator (PAM) with an EC50 of approximately 2 μM.
    MRS7935
  • HY-151387
    A2AAR antagonist 1
    		Antagonist
    A2AAR antagonist 1 (compound 21a) is an A2AAR (adenosine A2A receptor) antagonist with a Ki value of 20 nM. A2AAR antagonist 1 shows high ligand efficiency, and it can be used for the research of neurodegenerative diseases.
    A2AAR antagonist 1
  • HY-115862
    Benzo[c][1,8]naphthyridin-6(5H)-one
    Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM.
    Benzo[c][1,8]naphthyridin-6(5H)-one
  • HY-101854R
    N6-(2-Phenylethyl)adenosine (Standard)
    		Agonist
    N6-(2-Phenylethyl)adenosine (Standard) (N6-Phenethyladenosine (Standard)) is the analytical standard of N6-(2-Phenylethyl)adenosine (HY-101854). This product is intended for research and analytical applications. N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine), an adenosine derivative, is a potent adenosine receptors (AR) agonist with Ki values of 11.8 nM, 30.1 nM, 0.63 nM for rat A1AR, human A1AR and hA3AR, respectively.
    N6-(2-Phenylethyl)adenosine (Standard)
  • HY-A0181S6
    Adenosine monophosphate-13C10,15N5
    Adenosine monophosphate-13C10,15N5 (AMP-13C10,15N5) is the 13C- and 15N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
    Adenosine monophosphate-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub>
  • HY-123127
    CVT-2759 analog
    		Agonist
    CVT-2759 analog (compound 15) is a partial agonist of A1 adenosine receptor (Ki=167 nM) and can be used for the study of cardiac arrhythmias.
    CVT-2759 analog
  • HY-107203S
    Propentofylline-d6
    		Inhibitor
    Propentofylline-d6 (HWA 285-d6) is the deuterium labeled Propentofylline. Propentofylline is an orally active and brain-penetrant phosphodiesterase inhibitor. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders.
    Propentofylline-d<sub>6</sub>
  • HY-111088
    LUF5981
    		Antagonist
    LUF5981 is a relatively potent adenosine A2A receptor (A2A) antagonist with pIC50 value of 6.7.
    LUF5981
  • HY-B0004R
    Doxofylline (Standard)
    		Antagonist
    Doxofylline (Standard) is the analytical standard of Doxofylline. This product is intended for research and analytical applications. Doxofylline is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm.
    Doxofylline (Standard)
  • HY-103185R
    CCPA (Standard)
    		Agonist
    CCPA (2-Chloro-N6-cyclopentyladenosine (Standard)) is the analytical standard of CCPA (HY-103185). This product is intended for research and analytical applications. CCPA (2-Chloro-N6-cyclopentyladenosine) a highly selective A1 adenosine receptors agonist with a Ki of 0.4 nM. CCPA inhibits adenylate cyclase with an IC50 of 33 nM. CCPA exhibits anti-seizure and cardiacprotective activity. CCPA can be used for the research of seizure and myocardial infarction.
    CCPA (Standard)
  • HY-100678R
    CGS 15943 (Standard)
    		Antagonist
    CGS 15943 (Standard) is the analytical standard of CGS 15943. This product is intended for research and analytical applications. CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .
    CGS 15943 (Standard)
  • HY-19532R
    ZM241385 (Standard)
    		Antagonist
    ZM241385 (Standard) is the analytical standard of ZM241385. This product is intended for research and analytical applications. ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM.
    ZM241385 (Standard)
  • HY-123038
    CVT-5440
    		Antagonist
    CVT-5440 is a xanthine based, selective, high affinity A2B adenosine receptors (AdoR) antagonist with a Ki of 50 nM (selectivity A1> 200; A2A>200; A3>167). CVT-5440 has the potential for asthma research.
    CVT-5440
  • HY-19533R
    SCH 58261 (Standard)
    		Antagonist
    SCH 58261 (Standard) is the analytical standard of SCH 58261. This product is intended for research and analytical applications. SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively.
    SCH 58261 (Standard)
  • HY-N0127R
    Yohimbine Hydrochloride (Standard)
    		Inhibitor
    Yohimbine Hydrochloride Standard is an alpha-2 renal adenomatase receptor inhibitor, blocking pre- and post-contact alpha-2 renal adenomatase receptors, causing the release of renal adenoma and multiple sclerosis.
    Yohimbine Hydrochloride (Standard)
  • HY-118086
    MRS1067
    		Antagonist
    MRS 1067 is a competitive antagonist of the adenosine A3 receptor that inhibits the suppression of adenylate cyclase by adenosine A3 receptor agonists and affects the activation of G proteins. MRS 1067 can be used in research related to inflammation and cancer.
    MRS1067
  • HY-101139AR
    Xanthine amine congener hydrochloride (Standard)
    		Antagonist
    Xanthine amine congener (hydrochloride) (Standard) is the analytical standard of Xanthine amine congener (hydrochloride). This product is intended for research and analytical applications. Xanthine amine congener (XAC) hydrochloride is a non-selective adenosine receptor antagonist. Xanthine amine congener hydrochloride induces convulsions in mice.
    Xanthine amine congener hydrochloride (Standard)
  • HY-103182A
    PSB-1115 potassium salt
    		Antagonist
    PSB-1115 potassium salt is a selective A2B Adenosine Receptor antagonist. PSB-1115 potassium salt inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh).
    PSB-1115 potassium salt
  • HY-10889R
    Preladenant (Standard)
    		Antagonist
    Preladenant (Standard) is the analytical standard of Preladenant. This product is intended for research and analytical applications. Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.
    Preladenant (Standard)
Cat. No. 상품명 / Synonyms Application Reactivity
Adenosine Receptor Isoform Comparison

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